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1

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease

Jean C. Augustinack, Anja Schneider, Eva-Maria Mandelkow, Bradley T. Hyman

Journal:

Acta Neuropathologica

Year:

2002

Language:

english

File:

PDF, 215 KB

english, 2002

2

Tubulin hoops

MANDELKOW, EVA-MARIA, MANDELKOW, ECKHARD, UNWIN, NIGEL, COHEN, CAROLYN

Journal:

Year:

1977

File:

PDF, 717 KB

1977

3

Tau protein and tau aggregation inhibitors

Bruno Bulic, Marcus Pickhardt, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Neuropharmacology

Year:

2010

Language:

english

File:

PDF, 1.66 MB

english, 2010

4

P2-138: Prevention of tau aggregation in vitro and in cells by low molecular weight compounds derived from phenylthiazolyl-hydrazide or rhodanine core structures

Pickhardt, Marcus, Bulic, Bruno, Larbig, Gregor, Coksezen, Atilla, Biernat, Jacek, Khlistunova, Inna, Mandelkow, Eva-Maria, Schmidt, Boris, Waldmann, Herbert, Meyer, Bernd, Mandelkow, Eckhard

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

5

Unstained microtubules studied by cryo-electron microscopy

Mandelkow, Eva-Maria, Mandelkow, Eckhard

Journal:

Journal of Molecular Biology

Year:

1985

Language:

english

File:

PDF, 11.81 MB

english, 1985

6

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

Pickhardt, Marcus, Neumann, Thomas, Schwizer, Daniel, Callaway, Kari, Vendruscolo, Michele, Schenk, Dale, George-Hyslop, Peter, Mandelkow, Eva, Dobson, Christopher, McConlogue, Lisa, Mandelkow, Eckhar

Journal:

Current Alzheimer Research

Year:

2015

Language:

english

File:

PDF, 11.23 MB

english, 2015

7

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

Majewski, Jaroslaw, Jones, Emmalee M., Vander Zanden, Crystal M., Biernat, Jacek, Mandelkow, Eckhard, Chi, Eva Y.

Journal:

Scientific Reports

Year:

2020

File:

PDF, 3.26 MB

2020

8

Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy

Bruno Bulic, Marcus Pickhardt, Inna Khlistunova, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelkow, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 703 KB

english, 2007

9

Entwicklung von Inhibitoren der Tau-Aggregation bei Morbus Alzheimer

Bruno Bulic, Marcus Pickhardt, Boris Schmidt, Eva-Maria Mandelkow, Herbert Waldmann, Eckhard Mandelkow

Journal:

Angewandte Chemie

Year:

2009

Language:

german

File:

PDF, 1.41 MB

german, 2009

10

Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy

Dr. Ashutosh Kumar, Prof. Henrike Heise, Dr. Marcel J. J. Blommers, Dr. Philipp Krastel, Dr. Esther Schmitt, Dr. Frank Petersen, Dr. Siva Jeganathan, Dr. Eva-Maria Mandelkow, Dr. Teresa Carlomagno, Pr

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 680 KB

english, 2010

11

Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy

Bruno Bulic, Marcus Pickhardt, Inna Khlistunova, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelkow, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 703 KB

english, 2007

12

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

Bruno Bulic, Marcus Pickhardt, Boris Schmidt, Eva-Maria Mandelkow, Herbert Waldmann, Eckhard Mandelkow

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 1.41 MB

english, 2009

13

Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy

Dr. Ashutosh Kumar, Prof. Henrike Heise, Dr. Marcel J. J. Blommers, Dr. Philipp Krastel, Dr. Esther Schmitt, Dr. Frank Petersen, Dr. Siva Jeganathan, Dr. Eva-Maria Mandelkow, Dr. Teresa Carlomagno, Pr

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 699 KB

english, 2010

14

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles

Gerold Schmitt-Ulms, Dorthe Matenia, Gerard Drewes, Eva-Maria Mandelkow

Journal:

Year:

2009

Language:

english

File:

PDF, 470 KB

english, 2009

15

Interaction between kinesin, microtubules, and microtubule-associated protein 2

Alexander von Massow, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Year:

1989

Language:

english

File:

PDF, 1.12 MB

english, 1989

16

Microtubule oscillations

Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Year:

1992

Language:

english

File:

PDF, 1.15 MB

english, 1992

17

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila

Michelle L. Steinhilb, Dora Dias-Santagata, Erin E. Mulkearns, Joshua M. Shulman, Jacek Biernat, Eva-Maria Mandelkow, Mel B. Feany

Journal:

Journal of Neuroscience Research

Year:

2007

Language:

english

File:

PDF, 368 KB

english, 2007

18

Reconstructions of tubulin protofilaments: Different appearances of the same structure

Eckhard Mandelkow, Reiner Schultheiss, Eva-Maria Mandelkow

Journal:

Ultramicroscopy

Year:

1984

Language:

english

File:

PDF, 1.36 MB

english, 1984

19

Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25

Maryse Leost, Christiane Schultz, Andreas Link, Yong-Zhong Wu, Jacek Biernat, Eva-Maria Mandelkow, James A. Bibb, Gretchen L. Snyder, Paul Greengard, Daniel W. Zaharevitz, Rick Gussio, Adrian M. Sende

Journal:

Year:

2000

Language:

english

File:

PDF, 807 KB

english, 2000

20

Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model

Astrid Sydow, Ann Van der Jeugd, Fang Zheng, Tariq Ahmed, Detlef Balschun, Olga Petrova, Dagmar Drexler, Lepu Zhou, Gabriele Rune, Eckhard Mandelkow, Rudi D’Hooge, Christian Alzheimer, Eva-Maria Mande

Journal:

Journal of Molecular Neuroscience

Year:

2011

Language:

english

File:

PDF, 376 KB

english, 2011

21

Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid-β Peptides

Claire Goldsbury, Maria-Magdalena Mocanu, Edda Thies, Christoph Kaether, Christian Haass, Patrick Keller, Jacek Biernat, Eckhard Mandelkow, Eva-Maria Mandelkow

Journal:

Year:

2006

Language:

english

File:

PDF, 727 KB

english, 2006

22

Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease

Eckhard Mandelkow, Martin Von Bergen, Jacek Biernat, Eva-Maria Mandelkow

Journal:

Brain Pathology

Year:

2007

Language:

english

File:

PDF, 366 KB

english, 2007

23

X-ray kinetic studies of microtubule assembly using synchrotron radiation

Mandelkow, Eva-Maria, Harmsen, Arnold, Mandelkow, Eckhard, Bordas, Joan

Journal:

Year:

1980

File:

PDF, 615 KB

1980

24

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau

Ann Van der Jeugd, Katja Hochgräfe, Tariq Ahmed, Jochen M. Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D’Hooge, Eva-Maria Mandelkow

Journal:

Acta Neuropathologica

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

25

Structure of the Catalytic and Ubiquitin-Associated Domains of the Protein Kinase MARK/Par-1

Saravanan Panneerselvam, Alexander Marx, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Year:

2006

Language:

english

File:

PDF, 1.15 MB

english, 2006

26

The tau of MARK: a polarized view of the cytoskeleton

Dorthe Matenia, Eva-Maria Mandelkow

Journal:

Trends in Biochemical Sciences

Year:

2009

Language:

english

File:

PDF, 661 KB

english, 2009

27

Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease

Ute Preuss, Eva-Maria Mandelkow

Journal:

European Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 2.35 MB

english, 1998

28

The microtubule lattice — dynamic instability of concepts

Eckhard Mandelkow, Young-Hwa Song, Eva-Maria Mandelkow

Journal:

Trends in Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.29 MB

english, 1995

29

Kinesin motors and disease

Eckhard Mandelkow, Eva-Maria Mandelkow

Journal:

Trends in Cell Biology

Year:

2002

Language:

english

File:

PDF, 177 KB

english, 2002

30

Tau in Alzheimer's disease

Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Trends in Cell Biology

Year:

1998

Language:

english

File:

PDF, 102 KB

english, 1998

31

MAPs, MARKs and microtubule dynamics

Gerard Drewes, Andreas Ebneth, Eva-Maria Mandelkow

Journal:

Trends in Biochemical Sciences

Year:

1998

Language:

english

File:

PDF, 402 KB

english, 1998

32

Sequential phosphorylation of Tau by glycogen synthase kinase-3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

Qingyi Zheng-Fischhöfer, Jacek Biernat, Eva-Maria Mandelkow, Susanne Illenberger, Robert Godemann, Eckhard Mandelkow

Journal:

Year:

1998

Language:

english

File:

PDF, 807 KB

english, 1998

33

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

Thomas Timm, Alexander Marx, Saravanan Panneerselvam, Eckhard Mandelkow, Eva-Maria Mandelkow

Journal:

BMC Neuroscience

Year:

2008

Language:

english

File:

PDF, 1.48 MB

english, 2008

34

Tubulin oligomers and microtubule oscillations : Antagonistic role of microtubule stabilizers and destabilizers

Gudrun LANGE, Eva-Maria MANDELKOW, Annette JAGLA, Eckhard MANDELKOW

Journal:

Year:

1988

Language:

english

File:

PDF, 1.18 MB

english, 1988

35

Phenylthiazolyl-Hydrazide and Its Derivatives Are Potent Inhibitors of τ Aggregation and Toxicity in Vitro and in Cells†

Khlistunova, Inna, Coksezen, Atilla, Meyer, Bernd, Mandelkow, Eva-Maria, Schmidt, Boris, Mandelkow, Eckhard, Pickhardt, Marcus, Larbig, Gregor

Journal:

Year:

2007

Language:

english

File:

PDF, 367 KB

english, 2007

36

Proteolytic processing of tau

Wang, Yipeng, Garg, Sarika, Mandelkow, Eva-Maria, Mandelkow, Eckhard

Journal:

Biochemical Society Transactions

Year:

2010

Language:

english

File:

PDF, 179 KB

english, 2010

37

Crystallization of a Macromolecular Ring Assembly of Tubulin Liganded with the Anti-mitotic Drug Podophyllotoxin

Ernst Schönbrunn, Wolfgang Phlippen, Bernhard Trinczek, Stefan Sack, Susanne Eschenburg, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Journal of Structural Biology

Year:

1999

Language:

english

File:

PDF, 224 KB

english, 1999

38

Regulation of Alternative Splicing of Human Tau Exon 10 by Phosphorylation of Splicing Factors

Annette M. Hartmann, Dan Rujescu, Thomas Giannakouros, Eleni Nikolakaki, Michel Goedert, Eva-Maria Mandelkow, Qing Sheng Gao, Athena Andreadis, Stefan Stamm

Journal:

Molecular and Cellular Neuroscience

Year:

2001

Language:

english

File:

PDF, 250 KB

english, 2001

39

Fluorimetric studies on the influence of metal ions and chelators on the interaction between myosin and ATP

Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Year:

1973

Language:

english

File:

PDF, 470 KB

english, 1973

40

Microtubules and microtubule-associated proteins

Eckhard Mandelkow, Eva-Maria Mandelkow

Journal:

Current Opinion in Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.11 MB

english, 1995

41

Tau aggregation is driven by a transition from random coil to beta sheet structure

Martin von Bergen, Stefan Barghorn, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2005

Language:

english

File:

PDF, 788 KB

english, 2005

42

Surface-decoration of Microtubules by Human Tau

Rachel A Santarella, Georgios Skiniotis, Kenneth N Goldie, Peter Tittmann, Heinz Gross, Eva-Maria Mandelkow, E Mandelkow, Andreas Hoenger

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 9.75 MB

english, 2004

43

Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity

Catherine M. Moran, Michelle Donnelly, Daniela Ortiz, Harish C. Pant, Eva-Maria Mandelkow, Thomas B. Shea

Journal:

Molecular Brain Research

Year:

2005

Language:

english

File:

PDF, 303 KB

english, 2005

44

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

Sarika Garg, Thomas Timm, Eva-Maria Mandelkow, Eckhard Mandelkow, Yipeng Wang

Journal:

Neurobiology of Aging

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

45

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

Ulrike Krüger, Yipeng Wang, Satish Kumar, Eva-Maria Mandelkow

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 3.15 MB

english, 2012

46

46 Reversibility of cognitive decline and synapse loss in regulatable mice with tau pathology

Eva-Maria Mandelkow

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

47

Image reconstruction of tubulin hoops

Eckhard Mandelkow, Eva-maria Mandelkow

Journal:

Journal of Ultrastructure Research

Year:

1981

Language:

english

File:

PDF, 7.24 MB

english, 1981

48

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

Gerard Drewes, Andreas Ebneth, Ute Preuss, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Year:

1997

Language:

english

File:

PDF, 525 KB

english, 1997

49

Tau phosphorylation regulates cell process formation

Jacek Biernat, Yong Z. Wu, Laurent Meijer, Eva-Maria Mandelkow

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 192 KB

english, 2000

50

Rapid aggregation of tau protein into Alzheimer-like paired helical filaments reveals a nucleation-elongation mechanism

Martin von Bergen, Peter Friedhoff, Jacek Biernat, Eva-Maria Mandelkow, Eckhard Mandelkow

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 192 KB

english, 2000